Assay Detail
Binding
CHEMBL5341630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig brain tubulin polymerization in the presence of GTP by spectrophotometric analysis
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.52 | 6.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415595 | — | — | 2 | 6.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415595 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL5415595 | — | Inhibition | - | % | - |