Assay Detail
Binding
CHEMBL5342185
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Agonist activity at TLR1/TLR2 in human THP-1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Small-Molecule Modulators Targeting Toll-like Receptors for Potential Anticancer Therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.18 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472879 | — | — | 1 | 9.96 |
| CHEMBL4759149 | — | — | 1 | 8.31 |
| CHEMBL4581678 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472879 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL4759149 | — | EC50 | = | 4.88 | nM | 8.31 |
| CHEMBL4581678 | — | EC50 | = | 550.0 | nM | 6.26 |