Assay Detail
Binding
CHEMBL5342197
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Antagonist activity at human TLR8
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-Molecule Modulators Targeting Toll-like Receptors for Potential Anticancer Therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.95 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399590 | — | — | 1 | 10.00 |
| CHEMBL4790706 | — | — | 1 | 9.30 |
| CHEMBL5176610 | — | — | 1 | 9.15 |
| CHEMBL5397107 | — | — | 1 | 9.10 |
| CHEMBL5413646 | — | — | 1 | 9.00 |
| CHEMBL4553089 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399590 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4790706 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5176610 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5397107 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5413646 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4553089 | — | IC50 | = | 67.0 | nM | 7.17 |