Assay Detail
Binding
CHEMBL5343709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of AVPI-biotin from cIAP1 BIR3 domain (unknown origin) incubated for 2 hrs by DELFIA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.75 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4581366 | — | — | 1 | 7.85 |
| CHEMBL5403426 | — | — | 1 | 7.71 |
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4581366 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5403426 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL2431768 | LCL-161 | IC50 | = | 21.0 | nM | 7.68 |