Assay Detail
Functional
CHEMBL5344175
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Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 4 days by WST-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RS4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.75 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425705 | — | — | 1 | 8.34 |
| CHEMBL5409305 | — | — | 1 | 8.19 |
| CHEMBL4555209 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425705 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5409305 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4555209 | — | IC50 | = | 186.0 | nM | 6.73 |