Assay Detail
Binding
CHEMBL5344780
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Inhibition of HDAC3 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.78 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293858 | — | — | 1 | 7.27 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 7.17 |
| CHEMBL4078477 | — | — | 1 | 7.09 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.61 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293858 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4078477 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 1660.0 | nM | 5.78 |