Assay Detail
Functional
CHEMBL5344932
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Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.84 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406796 | — | — | 1 | 7.24 |
| CHEMBL4747331 | — | — | 1 | 6.89 |
| CHEMBL1951048 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406796 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4747331 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1951048 | — | IC50 | = | 410.0 | nM | 6.39 |