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Assay Detail

CHEMBL5345196

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Beta-hematin formation in Plasmodium falciparum K1 by spectrophotometric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Target

Hemozoin (CHEMBL613898)
Type MACROMOLECULE
Organism Plasmodium falciparum

Publication

Recent developments in antimalarial activities of 4-aminoquinoline derivatives.
Ravindar L, Hasbullah SA, Rakesh KP, Hassan NI.
Eur J Med Chem (2023) 256 : 115458 -115458
PubMed 37163950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.99 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5283588 1 6.54
CHEMBL5269049 1 6.47
CHEMBL5290580 1 6.35
CHEMBL5274289 1 6.34
CHEMBL5279554 1 6.30
CHEMBL5438011 1 6.28
CHEMBL5400681 1 6.14
CHEMBL5421567 1 6.04
CHEMBL5436922 1 6.01
CHEMBL5431287 1 5.96
CHEMBL5412382 1 5.94
CHEMBL5440295 1 5.88
CHEMBL5395232 1 5.77
CHEMBL5403702 1 5.75
CHEMBL5396909 1 5.62
CHEMBL5404715 1 5.58
CHEMBL5414628 1 5.52
CHEMBL5407263 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5283588 IC50 = 290.0 nM 6.54
CHEMBL5269049 IC50 = 340.0 nM 6.47
CHEMBL5290580 IC50 = 450.0 nM 6.35
CHEMBL5274289 IC50 = 460.0 nM 6.34
CHEMBL5279554 IC50 = 500.0 nM 6.30
CHEMBL5438011 IC50 = 520.0 nM 6.28
CHEMBL5400681 IC50 = 730.0 nM 6.14
CHEMBL5421567 IC50 = 920.0 nM 6.04
CHEMBL5436922 IC50 = 970.0 nM 6.01
CHEMBL5431287 IC50 = 1090.0 nM 5.96
CHEMBL5412382 IC50 = 1150.0 nM 5.94
CHEMBL5440295 IC50 = 1330.0 nM 5.88
CHEMBL5395232 IC50 = 1700.0 nM 5.77
CHEMBL5403702 IC50 = 1780.0 nM 5.75
CHEMBL5396909 IC50 = 2400.0 nM 5.62
CHEMBL5404715 IC50 = 2620.0 nM 5.58
CHEMBL5414628 IC50 = 3040.0 nM 5.52
CHEMBL5407263 IC50 = 5000.0 nM 5.30