Assay Detail
Functional
CHEMBL5345208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as reduction in parasite growth incubated for 36 hrs by Giemsa staining based microscopic analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent developments in antimalarial activities of 4-aminoquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.43 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.70 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 7.80 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.21 |
| CHEMBL170 | QUININE | 4.0 | 1 | 6.79 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.24 |
| CHEMBL5272909 | — | — | 1 | 4.41 |
| CHEMBL5274287 | — | — | 1 | 4.40 |
| CHEMBL4777661 | — | — | 1 | 4.40 |
| CHEMBL5427367 | — | — | 1 | 4.08 |
| CHEMBL5399088 | — | — | 1 | 4.05 |
| CHEMBL5399864 | — | — | 1 | 4.04 |
| CHEMBL5428303 | — | — | 1 | 4.03 |
| CHEMBL5437920 | — | — | 1 | - |
| CHEMBL5397950 | — | — | 1 | - |
| CHEMBL5415166 | — | — | 1 | - |
| CHEMBL5426453 | — | — | 1 | - |
| CHEMBL5275652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL170 | QUININE | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5272909 | — | IC50 | = | 38750.0 | nM | 4.41 |
| CHEMBL5274287 | — | IC50 | = | 39980.0 | nM | 4.40 |
| CHEMBL4777661 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5427367 | — | IC50 | = | 83550.0 | nM | 4.08 |
| CHEMBL5399088 | — | IC50 | = | 90020.0 | nM | 4.05 |
| CHEMBL5399864 | — | IC50 | = | 91940.0 | nM | 4.04 |
| CHEMBL5428303 | — | IC50 | = | 92770.0 | nM | 4.03 |
| CHEMBL5437920 | — | IC50 | = | 910140.0 | nM | - |
| CHEMBL5397950 | — | IC50 | = | 263120.0 | nM | - |
| CHEMBL5415166 | — | IC50 | = | 307290.0 | nM | - |
| CHEMBL5426453 | — | IC50 | = | 179560.0 | nM | - |
| CHEMBL5275652 | — | IC50 | = | 137100.0 | nM | - |