Assay Detail
Functional
CHEMBL5345240
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Antiplasmodial activity against Plasmodium falciparum K1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent developments in antimalarial activities of 4-aminoquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.01 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.22 |
| CHEMBL5440069 | — | — | 1 | 7.05 |
| CHEMBL5424835 | — | — | 1 | 6.22 |
| CHEMBL170 | QUININE | 4.0 | 1 | 6.08 |
| CHEMBL5421950 | — | — | 1 | 6.04 |
| CHEMBL5431880 | — | — | 1 | 5.95 |
| CHEMBL30323 | — | — | 1 | 5.49 |
| CHEMBL5430341 | — | — | 1 | 5.46 |
| CHEMBL4872202 | — | — | 1 | 5.31 |
| CHEMBL5423789 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5440069 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5424835 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL170 | QUININE | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5421950 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5431880 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL30323 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL5430341 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL4872202 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL5423789 | — | IC50 | = | 5510.0 | nM | 5.26 |