Assay Detail
Binding
CHEMBL5345441
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Binding affinity to human BRD4 BD 1 assessed as dissociation constant by ITC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecule Ligands of the BET-like Bromodomain, <i>Sm</i>BRD3, Affect <i>Schistosoma mansoni</i> Survival, Oviposition, and Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.76 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177300 | — | — | 1 | 8.21 |
| CHEMBL5407959 | — | — | 1 | 7.87 |
| CHEMBL5430618 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177300 | — | Kd | = | 6.23 | nM | 8.21 |
| CHEMBL5407959 | — | Kd | = | 13.5 | nM | 7.87 |
| CHEMBL5430618 | — | Kd | = | 64.4 | nM | 7.19 |