Assay Detail
Binding
CHEMBL5345470
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Binding affinity to HIV-1 NL4.3 hexameric capsid protein assessed as dissociation constant by SPR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Structural capsid protein (CHEMBL2366504) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.52 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788393 | — | — | 1 | 7.33 |
| CHEMBL5422125 | — | — | 1 | 6.70 |
| CHEMBL5419397 | — | — | 1 | 6.25 |
| CHEMBL4471665 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788393 | — | Kd | = | 47.0 | nM | 7.33 |
| CHEMBL5422125 | — | Kd | = | 199.0 | nM | 6.70 |
| CHEMBL5419397 | — | Kd | = | 561.0 | nM | 6.25 |
| CHEMBL4471665 | — | Kd | = | 1626.0 | nM | 5.79 |