Assay Detail
Functional
CHEMBL5345747
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Agonist activity at human GPR84 expressed in recombinant CHO cells harboring beta-galactosidase fragment assessed as inhibition of forskolin induced cAMP production incubated for 15 mins by radioactive [3H]cAMP based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.21 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444010 | — | — | 1 | 8.60 |
| CHEMBL124977 | — | — | 1 | 8.30 |
| CHEMBL4538049 | — | — | 1 | 8.15 |
| CHEMBL3827832 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444010 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL124977 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4538049 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3827832 | — | EC50 | = | 17.0 | nM | 7.77 |