Assay Detail
Binding
CHEMBL5345752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIK2 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase SIK2 (CHEMBL5699) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.01 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417444 | — | — | 1 | 9.15 |
| CHEMBL5438171 | — | — | 1 | 9.05 |
| CHEMBL5431938 | — | — | 1 | 8.64 |
| CHEMBL5427025 | — | — | 1 | 8.62 |
| CHEMBL5412961 | — | — | 1 | 8.60 |
| CHEMBL5404502 | — | — | 1 | 8.48 |
| CHEMBL5415380 | — | — | 1 | 8.48 |
| CHEMBL5397288 | — | — | 1 | 8.41 |
| CHEMBL5401167 | — | — | 1 | 8.10 |
| CHEMBL5396179 | — | — | 1 | 8.04 |
| CHEMBL5415699 | — | — | 1 | 7.98 |
| CHEMBL5403558 | — | — | 1 | 7.95 |
| CHEMBL5430774 | — | — | 1 | 7.84 |
| CHEMBL5420455 | — | — | 1 | 7.84 |
| CHEMBL5395705 | — | — | 1 | 7.84 |
| CHEMBL5419476 | — | — | 1 | 7.70 |
| CHEMBL5428147 | — | — | 1 | 7.69 |
| CHEMBL5428443 | — | — | 1 | 7.00 |
| CHEMBL5417490 | — | — | 1 | 6.52 |
| CHEMBL5410107 | — | — | 1 | 6.22 |
| CHEMBL5400669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417444 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5438171 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5431938 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5427025 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5412961 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5404502 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5415380 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5397288 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5401167 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5396179 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5415699 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL5403558 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5430774 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5420455 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL5395705 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5419476 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL5428147 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL5428443 | — | IC50 | = | 98.8 | nM | 7.00 |
| CHEMBL5417490 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5410107 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL5400669 | — | IC50 | > | 3920.0 | nM | - |