Assay Detail
Binding
CHEMBL5345756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AMPK alpha1/beta2/gamma1 (unknown origin) using SAMStide as substrate incubated for 45 to 60 mins in presence of 5'AMP and ATP by [33P]-gammaATP based Topcount scintillation counting analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.31 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438171 | — | — | 1 | 7.45 |
| CHEMBL5428147 | — | — | 1 | 7.15 |
| CHEMBL5412961 | — | — | 1 | 6.58 |
| CHEMBL5396179 | — | — | 1 | 6.28 |
| CHEMBL5404502 | — | — | 1 | 6.24 |
| CHEMBL5397288 | — | — | 1 | 6.19 |
| CHEMBL5401167 | — | — | 1 | 6.18 |
| CHEMBL5415699 | — | — | 1 | 6.11 |
| CHEMBL5403558 | — | — | 1 | 6.08 |
| CHEMBL5395705 | — | — | 1 | 6.05 |
| CHEMBL5419476 | — | — | 1 | 6.04 |
| CHEMBL5420455 | — | — | 1 | 6.03 |
| CHEMBL5427025 | — | — | 1 | 5.67 |
| CHEMBL5430774 | — | — | 1 | - |
| CHEMBL5428443 | — | — | 1 | - |
| CHEMBL5400669 | — | — | 1 | - |
| CHEMBL5410107 | — | — | 1 | - |
| CHEMBL5431938 | — | — | 1 | - |
| CHEMBL5417490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438171 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL5428147 | — | IC50 | = | 70.8 | nM | 7.15 |
| CHEMBL5412961 | — | IC50 | = | 263.2 | nM | 6.58 |
| CHEMBL5396179 | — | IC50 | = | 531.2 | nM | 6.28 |
| CHEMBL5404502 | — | IC50 | = | 582.2 | nM | 6.24 |
| CHEMBL5397288 | — | IC50 | = | 648.7 | nM | 6.19 |
| CHEMBL5401167 | — | IC50 | = | 658.6 | nM | 6.18 |
| CHEMBL5415699 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL5403558 | — | IC50 | = | 832.5 | nM | 6.08 |
| CHEMBL5395705 | — | IC50 | = | 884.8 | nM | 6.05 |
| CHEMBL5419476 | — | IC50 | = | 913.7 | nM | 6.04 |
| CHEMBL5420455 | — | IC50 | = | 929.4 | nM | 6.03 |
| CHEMBL5427025 | — | IC50 | = | 2127.0 | nM | 5.67 |
| CHEMBL5430774 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL5428443 | — | IC50 | - | — | - | |
| CHEMBL5400669 | — | IC50 | - | — | - | |
| CHEMBL5410107 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL5431938 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL5417490 | — | IC50 | - | — | - |