Assay Detail
Binding
CHEMBL5346244
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Binding affinity to human recombinant full length N-terminal Alexa647-NHS labeled cardiac troponin C expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incubated for 20 mins by microscale thermophoresis analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Troponin C, slow skeletal and cardiac muscles (CHEMBL2066) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.10 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169107 | — | — | 1 | 5.82 |
| CHEMBL1191567 | — | — | 1 | 5.72 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.30 |
| CHEMBL485099 | — | — | 1 | 5.08 |
| CHEMBL5430893 | — | — | 1 | 4.59 |
| CHEMBL5429897 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169107 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL1191567 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL314854 | FINGOLIMOD | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL485099 | — | Kd | = | 8400.0 | nM | 5.08 |
| CHEMBL5430893 | — | Kd | = | 25700.0 | nM | 4.59 |
| CHEMBL5429897 | — | Kd | = | 77300.0 | nM | 4.11 |