Assay Detail
Binding
CHEMBL5346246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of N-terminal FAM labeled cTNI switch peptide probe from human full length cardiac troponin C in presence of CaCl2 by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Troponin C, slow skeletal and cardiac muscles (CHEMBL2066) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.45 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1191567 | — | — | 1 | 4.66 |
| CHEMBL169107 | — | — | 1 | 4.58 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 4.54 |
| CHEMBL485099 | — | — | 1 | 4.37 |
| CHEMBL5430893 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1191567 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL169107 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL485099 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL5430893 | — | IC50 | = | 75800.0 | nM | 4.12 |