Assay Detail
Functional
CHEMBL5346399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.80 | 6.82 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1951048 | — | — | 1 | 6.82 |
| CHEMBL5400214 | — | — | 1 | 6.36 |
| CHEMBL5436750 | — | — | 1 | 6.12 |
| CHEMBL5409661 | — | — | 1 | 6.05 |
| CHEMBL5421719 | — | — | 1 | 5.92 |
| CHEMBL5407359 | — | — | 1 | 5.87 |
| CHEMBL5432834 | — | — | 1 | 5.87 |
| CHEMBL5427609 | — | — | 1 | 5.81 |
| CHEMBL5439964 | — | — | 1 | 5.77 |
| CHEMBL5396647 | — | — | 1 | 5.74 |
| CHEMBL5395708 | — | — | 1 | 5.68 |
| CHEMBL5394359 | — | — | 1 | 5.67 |
| CHEMBL5407023 | — | — | 1 | 5.67 |
| CHEMBL5435808 | — | — | 1 | 5.64 |
| CHEMBL5402474 | — | — | 1 | 5.63 |
| CHEMBL5437821 | — | — | 1 | 5.49 |
| CHEMBL5397336 | — | — | 1 | 5.35 |
| CHEMBL5438589 | — | — | 1 | 5.33 |
| CHEMBL5436413 | — | — | 1 | 5.32 |
| CHEMBL5425891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1951048 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5400214 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL5436750 | — | IC50 | = | 767.0 | nM | 6.12 |
| CHEMBL5409661 | — | IC50 | = | 889.0 | nM | 6.05 |
| CHEMBL5421719 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL5407359 | — | IC50 | = | 1349.0 | nM | 5.87 |
| CHEMBL5432834 | — | IC50 | = | 1361.0 | nM | 5.87 |
| CHEMBL5427609 | — | IC50 | = | 1543.0 | nM | 5.81 |
| CHEMBL5439964 | — | IC50 | = | 1685.0 | nM | 5.77 |
| CHEMBL5396647 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5395708 | — | IC50 | = | 2068.0 | nM | 5.68 |
| CHEMBL5394359 | — | IC50 | = | 2165.0 | nM | 5.67 |
| CHEMBL5407023 | — | IC50 | = | 2137.0 | nM | 5.67 |
| CHEMBL5435808 | — | IC50 | = | 2294.0 | nM | 5.64 |
| CHEMBL5402474 | — | IC50 | = | 2352.0 | nM | 5.63 |
| CHEMBL5437821 | — | IC50 | = | 3236.0 | nM | 5.49 |
| CHEMBL5397336 | — | IC50 | = | 4454.0 | nM | 5.35 |
| CHEMBL5438589 | — | IC50 | = | 4733.0 | nM | 5.33 |
| CHEMBL5436413 | — | IC50 | = | 4765.0 | nM | 5.32 |
| CHEMBL5425891 | — | Inhibition | - | % | - |