Assay Detail
Binding
CHEMBL5346610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5-HT1DR (unknown origin) assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.88 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1185 | ZOLMITRIPTAN | 4.0 | 1 | 9.40 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 9.30 |
| CHEMBL1278 | NARATRIPTAN | 4.0 | 1 | 8.82 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 8.52 |
| CHEMBL1279 | FROVATRIPTAN | 4.0 | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1185 | ZOLMITRIPTAN | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1278 | NARATRIPTAN | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL905 | RIZATRIPTAN | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1279 | FROVATRIPTAN | Ki | = | 4.4 | nM | 8.36 |