Assay Detail
Binding
CHEMBL5346634
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Binding affinity to human beta 2 adrenergic receptor assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.56 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 10.40 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 9.72 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 9.49 |
| CHEMBL601773 | DIHYDROERGOCRISTINE | -1.0 | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL723 | CARVEDILOL | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL500 | PINDOLOL | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL601773 | DIHYDROERGOCRISTINE | Ki | = | 2.4 | nM | 8.62 |