Assay Detail
Binding
CHEMBL5346703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal hexa-histidine tagged recombinant SARS-CoV-2 nsp14 RNA cap N7-methyltransferase activity expressed in Escherichia coli C2566 using GpppAC4 synthetic RNA and [3H]-SAM as substrate incubated for 30 mins by filter binding assay based liquid scintillation counter analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
<i>N</i>-Arylsulfonamide-based adenosine analogues to target RNA cap <i>N</i>7-methyltransferase nsp14 of SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.20 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 6.56 |
| CHEMBL5411147 | — | — | 1 | 6.05 |
| CHEMBL5421616 | — | — | 1 | 6.05 |
| CHEMBL5418419 | — | — | 1 | 5.69 |
| CHEMBL5406405 | — | — | 1 | 5.66 |
| CHEMBL5437799 | — | — | 1 | 5.34 |
| CHEMBL5423053 | — | — | 1 | 5.33 |
| CHEMBL5403276 | — | — | 1 | 5.14 |
| CHEMBL5409052 | — | — | 1 | 4.81 |
| CHEMBL5420170 | — | — | 1 | 4.63 |
| CHEMBL5439086 | — | — | 1 | 4.56 |
| CHEMBL5438646 | — | — | 1 | 4.42 |
| CHEMBL5410336 | — | — | 1 | 4.31 |
| CHEMBL5394078 | — | — | 1 | 4.28 |
| CHEMBL5429136 | — | — | 1 | - |
| CHEMBL5412699 | — | — | 1 | - |
| CHEMBL5439737 | — | — | 1 | - |
| CHEMBL5437349 | — | — | 1 | - |
| CHEMBL5396255 | — | — | 1 | - |
| CHEMBL5397749 | — | — | 1 | - |
| CHEMBL5419451 | — | — | 1 | - |
| CHEMBL5422414 | — | — | 1 | - |
| CHEMBL5429277 | — | — | 1 | - |
| CHEMBL5434990 | — | — | 1 | - |
| CHEMBL5426066 | — | — | 1 | - |
| CHEMBL5430883 | — | — | 1 | - |
| CHEMBL5402533 | — | — | 1 | - |
| CHEMBL5432305 | — | — | 1 | - |
| CHEMBL5412863 | — | — | 1 | - |
| CHEMBL5428845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL5411147 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5421616 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5418419 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5406405 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5437799 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5423053 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5403276 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5409052 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5420170 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL5439086 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL5438646 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL5410336 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL5394078 | — | IC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL5400552 | — | IC50 | - | — | - | |
| CHEMBL5401955 | — | IC50 | - | — | - | |
| CHEMBL5429136 | — | IC50 | - | — | - | |
| CHEMBL5412699 | — | IC50 | - | — | - | |
| CHEMBL5439737 | — | IC50 | - | — | - | |
| CHEMBL5437349 | — | IC50 | - | — | - | |
| CHEMBL5396255 | — | IC50 | - | — | - | |
| CHEMBL5397749 | — | IC50 | - | — | - | |
| CHEMBL5419451 | — | IC50 | - | — | - | |
| CHEMBL5422414 | — | IC50 | - | — | - | |
| CHEMBL5429277 | — | IC50 | - | — | - | |
| CHEMBL5434990 | — | IC50 | - | — | - | |
| CHEMBL5426066 | — | IC50 | - | — | - | |
| CHEMBL5430883 | — | IC50 | - | — | - | |
| CHEMBL5402533 | — | IC50 | - | — | - | |
| CHEMBL5432305 | — | IC50 | - | — | - | |
| CHEMBL5412863 | — | IC50 | - | — | - | |
| CHEMBL5428845 | — | IC50 | - | — | - |