Assay Detail
Binding
CHEMBL5346985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.11 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495727 | AT-9283 | 2.0 | 1 | 8.96 |
| CHEMBL4116008 | CERDULATINIB | 2.0 | 1 | 8.10 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495727 | AT-9283 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4116008 | CERDULATINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 55.0 | nM | 7.26 |