Assay Detail
Functional
CHEMBL5347344
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Antiviral activity against Coxsackievirus 21 infected in human HeLa cells assessed as reduction of virus induced cytopathic effect incubated for 3 days by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus A21 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.48 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5409037 | — | — | 1 | 4.70 |
| CHEMBL5434203 | — | — | 1 | 4.50 |
| CHEMBL389706 | — | — | 1 | 4.44 |
| CHEMBL5399680 | — | — | 1 | 4.26 |
| CHEMBL5409662 | — | — | 1 | - |
| CHEMBL5405401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5409037 | — | EC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5434203 | — | EC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL389706 | — | EC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL5399680 | — | EC50 | = | 54600.0 | nM | 4.26 |
| CHEMBL5409662 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5405401 | — | EC50 | > | 100000.0 | nM | - |