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Compound Detail

CHEMBL389706

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Cc1cccc(CNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1

Basic Information

ChEMBL ID CHEMBL389706
Phase Preclinical
Structure Type MOL
InChI Key WBJVJFOITZTVRG-SCFUHWHPSA-N
6
Targets
8
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

371.4
MW (Da)
0.36
ALogP
9
HBA
4
HBD
125.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H21N5O4
MW 371.40
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness 0.25

Activity Summary

IC50 5 meas. best 5.19
EC50 3 meas. best 7.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Enterovirus A71
CHEMBL612436
EC50 7.03 7.03 94.0 1
HL-60
CHEMBL383
IC50 5.19 5.19 6400.0 1
Adenosine kinase
CHEMBL2982
IC50 5.07 5.07 8491.8 2
enterovirus D68
CHEMBL613204
EC50 5.05 5.05 8900.0 1
CCRF-CEM
CHEMBL382
IC50 4.72 4.72 19100.0 1
Coxsackievirus A21
CHEMBL613553
EC50 4.44 4.44 36400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine