Assay Detail
Functional
CHEMBL5347345
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Antiviral activity against Human enterovirus 68 infected in human HeLa cells assessed as reduction of virus induced cytopathic effect incubated for 3 days by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | enterovirus D68 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.55 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389706 | — | — | 1 | 5.05 |
| CHEMBL5409037 | — | — | 1 | 4.04 |
| CHEMBL5409662 | — | — | 1 | - |
| CHEMBL5399680 | — | — | 1 | - |
| CHEMBL5434203 | — | — | 1 | - |
| CHEMBL5405401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389706 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5409037 | — | EC50 | = | 91200.0 | nM | 4.04 |
| CHEMBL5409662 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5399680 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5434203 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5405401 | — | EC50 | > | 100000.0 | nM | - |