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Assay Detail

CHEMBL5347334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against human Enterovirus 71 BrCr infected in human RD cells assessed as reduction of virus induced cytopathic effect incubated for 3 days by MTS assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Enterovirus A71
Cell Type RD
Confidence 1 — Organism
Curated By Autocuration

Target

Enterovirus A71 (CHEMBL612436)
Type ORGANISM
Organism Enterovirus A71

Publication

Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71.
Salerno M, Varricchio C, Bevilacqua F, Jochmans D, Neyts J, Brancale A, Ferla S, Bassetto M.
Eur J Med Chem (2023) 246 : 114942 -114942
PubMed 36455356 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 27 6.42 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20210 RUPINTRIVIR 2.0 1 8.05
CHEMBL5398007 1 7.77
CHEMBL225766 1 7.44
CHEMBL5426548 1 7.19
CHEMBL389706 1 7.03
CHEMBL5409037 1 7.00
CHEMBL5434203 1 6.99
CHEMBL193385 1 6.97
CHEMBL387918 1 6.93
CHEMBL225731 1 6.63
CHEMBL5431300 1 6.28
CHEMBL5413981 1 6.22
CHEMBL5409662 1 6.05
CHEMBL5405401 1 5.97
CHEMBL5429284 1 5.73
CHEMBL5420693 1 5.58
CHEMBL5439874 1 5.38
CHEMBL5399680 1 5.35
CHEMBL5421815 1 5.09
CHEMBL5398861 1 4.72
CHEMBL5427535 1 -
CHEMBL5408202 1 -
CHEMBL5406614 1 -
CHEMBL191760 1 -
CHEMBL4065616 REMDESIVIR 4.0 1 -
CHEMBL236207 BETA-2'-C-METHYL-7-DEAZA-ADENOSINE 1 -
CHEMBL5418610 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20210 RUPINTRIVIR EC50 = 9.0 nM 8.05
CHEMBL5398007 EC50 = 17.0 nM 7.77
CHEMBL225766 EC50 = 36.0 nM 7.44
CHEMBL5426548 EC50 = 65.0 nM 7.19
CHEMBL389706 EC50 = 94.0 nM 7.03
CHEMBL5409037 EC50 = 101.0 nM 7.00
CHEMBL5434203 EC50 = 102.0 nM 6.99
CHEMBL193385 EC50 = 106.0 nM 6.97
CHEMBL387918 EC50 = 117.0 nM 6.93
CHEMBL225731 EC50 = 236.0 nM 6.63
CHEMBL5431300 EC50 = 530.0 nM 6.28
CHEMBL5413981 EC50 = 600.0 nM 6.22
CHEMBL5409662 EC50 = 898.0 nM 6.05
CHEMBL5405401 EC50 = 1070.0 nM 5.97
CHEMBL5429284 EC50 = 1850.0 nM 5.73
CHEMBL5420693 EC50 = 2610.0 nM 5.58
CHEMBL5439874 EC50 = 4210.0 nM 5.38
CHEMBL5399680 EC50 = 4500.0 nM 5.35
CHEMBL5421815 EC50 = 8050.0 nM 5.09
CHEMBL5398861 EC50 = 19000.0 nM 4.72
CHEMBL5427535 EC50 > 75000.0 nM -
CHEMBL5408202 EC50 > 100000.0 nM -
CHEMBL5406614 EC50 > 100000.0 nM -
CHEMBL191760 EC50 > 100000.0 nM -
CHEMBL4065616 REMDESIVIR EC50 - -
CHEMBL236207 BETA-2'-C-METHYL-7-DEAZA-ADENOSINE EC50 - -
CHEMBL5418610 EC50 > 20000.0 nM -