Assay Detail
Binding
CHEMBL5347350
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Inhibition of P13Kbeta (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.57 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3544966 | GSK-1059615 | 1.0 | 1 | 9.22 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 8.43 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.57 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.36 |
| CHEMBL3813842 | PAXALISIB | 2.0 | 1 | 7.34 |
| CHEMBL5278435 | — | — | 1 | 7.26 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 7.17 |
| CHEMBL3545366 | VOXTALISIB | 2.0 | 1 | 6.96 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3544966 | GSK-1059615 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3813842 | PAXALISIB | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5278435 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3545366 | VOXTALISIB | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 166.0 | nM | 6.78 |