Assay Detail
Binding
CHEMBL5347353
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.69 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336325 | VISTUSERTIB | 2.0 | 1 | 8.55 |
| CHEMBL589258 | — | — | 1 | 8.52 |
| CHEMBL5278435 | — | — | 1 | 7.92 |
| CHEMBL3544966 | GSK-1059615 | 1.0 | 1 | 7.92 |
| CHEMBL5439799 | — | — | 1 | 7.80 |
| CHEMBL4071083 | — | — | 1 | 7.80 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.77 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.68 |
| CHEMBL3813842 | PAXALISIB | 2.0 | 1 | 7.16 |
| CHEMBL1234429 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336325 | VISTUSERTIB | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL589258 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5278435 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3544966 | GSK-1059615 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5439799 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4071083 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL3813842 | PAXALISIB | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1234429 | — | IC50 | = | 1760.0 | nM | 5.75 |