Assay Detail
Binding
CHEMBL5348490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of plasmodium falciparum PK6 incubated for 2 hrs by luciferin-based luminescence assay
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cdk-related protein kinase 6 (CHEMBL3301558) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 84 | 7.78 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398401 | — | — | 1 | 9.54 |
| CHEMBL5433238 | — | — | 1 | 9.36 |
| CHEMBL5418962 | — | — | 1 | 9.09 |
| CHEMBL5398147 | — | — | 1 | 9.08 |
| CHEMBL5426653 | — | — | 1 | 9.00 |
| CHEMBL5395319 | — | — | 1 | 8.96 |
| CHEMBL5435885 | — | — | 1 | 8.96 |
| CHEMBL5419731 | — | — | 1 | 8.92 |
| CHEMBL5413903 | — | — | 1 | 8.92 |
| CHEMBL5438128 | — | — | 1 | 8.92 |
| CHEMBL5439780 | — | — | 1 | 8.89 |
| CHEMBL5393906 | — | — | 1 | 8.89 |
| CHEMBL5396897 | — | — | 1 | 8.82 |
| CHEMBL5402319 | — | — | 1 | 8.80 |
| CHEMBL5427384 | — | — | 1 | 8.77 |
| CHEMBL5405690 | — | — | 1 | 8.74 |
| CHEMBL5396095 | — | — | 1 | 8.74 |
| CHEMBL5404309 | — | — | 1 | 8.72 |
| CHEMBL5414363 | — | — | 1 | 8.72 |
| CHEMBL5405119 | — | — | 1 | 8.72 |
| CHEMBL5431272 | — | — | 1 | 8.70 |
| CHEMBL5438744 | — | — | 1 | 8.70 |
| CHEMBL5435130 | — | — | 1 | 8.68 |
| CHEMBL5414544 | — | — | 1 | 8.57 |
| CHEMBL5440849 | — | — | 1 | 8.55 |
| CHEMBL5407751 | — | — | 1 | 8.51 |
| CHEMBL247228 | GW770249X | — | 1 | 8.28 |
| CHEMBL5407060 | — | — | 1 | 8.09 |
| CHEMBL5395335 | — | — | 1 | 8.07 |
| CHEMBL368252 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398401 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL5433238 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5418962 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL5398147 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL5426653 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5395319 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5435885 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5419731 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5413903 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5438128 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5439780 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5393906 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5396897 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5402319 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5427384 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5405690 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5396095 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5404309 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5414363 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5405119 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5431272 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5438744 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5435130 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5414544 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5440849 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5407751 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL247228 | GW770249X | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5407060 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5395335 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL368252 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5415457 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5417033 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5400583 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5417668 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5414579 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5421495 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL178455 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5429163 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5405467 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL360526 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5435242 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5426500 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5425086 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5399124 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5428638 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5397928 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5433709 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5420208 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5420399 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5394986 | — | IC50 | = | 124.0 | nM | 6.91 |