Compound Detail
CHEMBL360526
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Basic Information
| ChEMBL ID | CHEMBL360526 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WEDWUMJCHQDOEH-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
451.4
MW (Da)
5.97
ALogP
5
HBA
2
HBD
81.7
PSA (Ų)
0.38
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 8.47 | 8.47 | 3.4 | 1 |
| Cdk-related protein kinase 6 CHEMBL3301558 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 0.7 | nM | 9.15 | Inhibition of vascular endothelial growth factor receptor 2 | 15743179 |
| Platelet-derived growth factor receptor alpha | IC50 | = | 3.4 | nM | 8.47 | Inhibition of platelet-derived growth factor receptor alpha | 15743179 |
| Cdk-related protein kinase 6 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of plasmodium falciparum PK6 incubated for 2 hrs by luciferin-based l... | 36736152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36736152 | 10.1016/j.ejmech.2022.115043 | Cdk-related protein kinase 6 | 2 |
| 15743179 | 10.1021/jm030427r | Vascular endothelial growth factor receptor 2 | 1 |
| 15743179 | 10.1021/jm030427r | Platelet-derived growth factor receptor alpha | 1 |
Data from ChEMBL 36 via Core Engine