Assay Detail
Binding
CHEMBL832771
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Inhibition of platelet-derived growth factor receptor alpha
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.97 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179698 | — | — | 1 | 8.80 |
| CHEMBL179593 | — | — | 1 | 8.70 |
| CHEMBL178156 | — | — | 1 | 8.70 |
| CHEMBL369760 | — | — | 1 | 8.48 |
| CHEMBL360526 | — | — | 1 | 8.47 |
| CHEMBL179307 | — | — | 1 | 8.46 |
| CHEMBL179603 | — | — | 1 | 8.44 |
| CHEMBL368252 | — | — | 1 | 8.44 |
| CHEMBL179061 | — | — | 1 | 8.44 |
| CHEMBL179227 | — | — | 1 | 8.41 |
| CHEMBL179522 | — | — | 1 | 8.33 |
| CHEMBL426047 | — | — | 1 | 8.24 |
| CHEMBL180331 | — | — | 1 | 8.24 |
| CHEMBL426602 | — | — | 1 | 8.19 |
| CHEMBL360781 | — | — | 1 | 8.17 |
| CHEMBL179719 | — | — | 1 | 8.17 |
| CHEMBL179816 | — | — | 1 | 8.00 |
| CHEMBL179165 | — | — | 1 | 8.00 |
| CHEMBL362486 | — | — | 1 | 7.85 |
| CHEMBL178568 | — | — | 1 | 7.77 |
| CHEMBL179360 | — | — | 1 | 7.75 |
| CHEMBL179753 | — | — | 1 | 7.68 |
| CHEMBL362188 | — | — | 1 | 7.62 |
| CHEMBL178981 | — | — | 1 | 7.62 |
| CHEMBL362634 | — | — | 1 | 7.44 |
| CHEMBL179422 | — | — | 1 | 7.43 |
| CHEMBL369747 | — | — | 1 | 7.37 |
| CHEMBL178276 | — | — | 1 | 7.28 |
| CHEMBL359617 | — | — | 1 | 7.26 |
| CHEMBL440202 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179698 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL179593 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL178156 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL369760 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL360526 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL179307 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL179603 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL368252 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL179061 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL179227 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL179522 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL426047 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL180331 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL426602 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL179719 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL360781 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL179816 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL179165 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL362486 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL178568 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL179360 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL179753 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL362188 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL178981 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL362634 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL179422 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL369747 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL178276 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL359617 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL440202 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL179450 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL179082 | — | IC50 | < | 10.0 | nM | - |