Compound Detail
CHEMBL179450
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Basic Information
| ChEMBL ID | CHEMBL179450 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NCUVIXBQXJETKF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
459.5
MW (Da)
5.06
ALogP
8
HBA
3
HBD
100.5
PSA (Ų)
0.18
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.26 | 7.26 | 55.0 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 6.31 | 6.31 | 490.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 55.0 | nM | 7.26 | Inhibition of vascular endothelial growth factor receptor 2 | 15743179 |
| Platelet-derived growth factor receptor alpha | IC50 | = | 490.0 | nM | 6.31 | Inhibition of platelet-derived growth factor receptor alpha | 15743179 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15743179 | 10.1021/jm030427r | Vascular endothelial growth factor receptor 2 | 1 |
| 15743179 | 10.1021/jm030427r | Platelet-derived growth factor receptor alpha | 1 |
Data from ChEMBL 36 via Core Engine