Assay Detail
Binding
CHEMBL876146
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Inhibition of vascular endothelial growth factor receptor 2
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.75 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368252 | — | — | 1 | 9.70 |
| CHEMBL426047 | — | — | 1 | 9.70 |
| CHEMBL369760 | — | — | 1 | 9.70 |
| CHEMBL179165 | — | — | 1 | 9.70 |
| CHEMBL279351 | — | — | 1 | 9.40 |
| CHEMBL180331 | — | — | 1 | 9.40 |
| CHEMBL179522 | — | — | 1 | 9.40 |
| CHEMBL179227 | — | — | 1 | 9.30 |
| CHEMBL362634 | — | — | 1 | 9.30 |
| CHEMBL179698 | — | — | 1 | 9.15 |
| CHEMBL360526 | — | — | 1 | 9.15 |
| CHEMBL179593 | — | — | 1 | 8.96 |
| CHEMBL179360 | — | — | 1 | 8.96 |
| CHEMBL179719 | — | — | 1 | 8.96 |
| CHEMBL426602 | — | — | 1 | 8.92 |
| CHEMBL362188 | — | — | 1 | 8.80 |
| CHEMBL179307 | — | — | 1 | 8.74 |
| CHEMBL179816 | — | — | 1 | 8.74 |
| CHEMBL179603 | — | — | 1 | 8.66 |
| CHEMBL179061 | — | — | 1 | 8.64 |
| CHEMBL360349 | — | — | 1 | 8.59 |
| CHEMBL359617 | — | — | 1 | 8.43 |
| CHEMBL178568 | — | — | 1 | 8.25 |
| CHEMBL179422 | — | — | 1 | 8.25 |
| CHEMBL362486 | — | — | 1 | 8.23 |
| CHEMBL369747 | — | — | 1 | 8.22 |
| CHEMBL440202 | — | — | 1 | 8.05 |
| CHEMBL360781 | — | — | 1 | 7.72 |
| CHEMBL178981 | — | — | 1 | 7.57 |
| CHEMBL179082 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368252 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL179165 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL369760 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL426047 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL279351 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL180331 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL179522 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL179227 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL362634 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL179698 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL360526 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL179593 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL179360 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL179719 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL426602 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL362188 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL179816 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL179307 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL179603 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL179061 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL360349 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL359617 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL178568 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL179422 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL362486 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL369747 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL440202 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL360781 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL178981 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL179082 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL179450 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL178156 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL178276 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL179753 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL179815 | — | IC50 | < | 1.0 | nM | - |