Compound Detail
CHEMBL178276
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Basic Information
| ChEMBL ID | CHEMBL178276 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHXXFDZXNXYYOB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
449.5
MW (Da)
6.21
ALogP
5
HBA
2
HBD
65.0
PSA (Ų)
0.21
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 7.28 | 7.28 | 52.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor alpha | IC50 | = | 52.0 | nM | 7.28 | Inhibition of platelet-derived growth factor receptor alpha | 15743179 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15743179 | 10.1021/jm030427r | Vascular endothelial growth factor receptor 2 | 1 |
| 15743179 | 10.1021/jm030427r | Platelet-derived growth factor receptor alpha | 1 |
Data from ChEMBL 36 via Core Engine