Assay Detail
Functional
CHEMBL5350194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by Cell counting kit 8 method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.89 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436527 | — | — | 1 | 8.03 |
| CHEMBL5439595 | — | — | 1 | 7.90 |
| CHEMBL5440092 | — | — | 1 | 7.81 |
| CHEMBL5427478 | — | — | 1 | 7.77 |
| CHEMBL5420584 | — | — | 1 | 7.75 |
| CHEMBL5404060 | — | — | 1 | 7.68 |
| CHEMBL5431098 | — | — | 1 | 7.58 |
| CHEMBL5413844 | — | — | 1 | 7.48 |
| CHEMBL5409484 | — | — | 1 | 7.42 |
| CHEMBL5434390 | — | — | 1 | 7.26 |
| CHEMBL5411218 | — | — | 1 | 7.15 |
| CHEMBL5419075 | — | — | 1 | 6.99 |
| CHEMBL5410318 | — | — | 1 | 6.94 |
| CHEMBL5407229 | — | — | 1 | 6.67 |
| CHEMBL5432091 | — | — | 1 | 6.45 |
| CHEMBL5435060 | — | — | 1 | 6.42 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 6.07 |
| CHEMBL5422680 | — | — | 1 | 5.85 |
| CHEMBL5425019 | — | — | 1 | 5.82 |
| CHEMBL5405058 | — | — | 1 | 5.77 |
| CHEMBL5403437 | — | — | 1 | 5.66 |
| CHEMBL5423534 | — | — | 1 | 5.05 |
| CHEMBL5398223 | — | — | 1 | - |
| CHEMBL5417909 | — | — | 1 | - |
| CHEMBL5394490 | — | — | 1 | - |
| CHEMBL5425458 | — | — | 1 | - |
| CHEMBL5413779 | — | — | 1 | - |
| CHEMBL5403131 | — | — | 1 | - |
| CHEMBL5403709 | — | — | 1 | - |
| CHEMBL5439019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436527 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5439595 | — | IC50 | = | 12.63 | nM | 7.90 |
| CHEMBL5440092 | — | IC50 | = | 15.49 | nM | 7.81 |
| CHEMBL5427478 | — | IC50 | = | 16.85 | nM | 7.77 |
| CHEMBL5420584 | — | IC50 | = | 17.77 | nM | 7.75 |
| CHEMBL5404060 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL5431098 | — | IC50 | = | 26.12 | nM | 7.58 |
| CHEMBL5413844 | — | IC50 | = | 32.89 | nM | 7.48 |
| CHEMBL5409484 | — | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL5434390 | — | IC50 | = | 54.3 | nM | 7.26 |
| CHEMBL5411218 | — | IC50 | = | 71.3 | nM | 7.15 |
| CHEMBL5419075 | — | IC50 | = | 102.62 | nM | 6.99 |
| CHEMBL5410318 | — | IC50 | = | 114.4 | nM | 6.94 |
| CHEMBL5407229 | — | IC50 | = | 216.4 | nM | 6.67 |
| CHEMBL5432091 | — | IC50 | = | 356.1 | nM | 6.45 |
| CHEMBL5435060 | — | IC50 | = | 384.5 | nM | 6.42 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 850.9 | nM | 6.07 |
| CHEMBL5422680 | — | IC50 | = | 1406.0 | nM | 5.85 |
| CHEMBL5425019 | — | IC50 | = | 1517.0 | nM | 5.82 |
| CHEMBL5405058 | — | IC50 | = | 1714.0 | nM | 5.77 |
| CHEMBL5403437 | — | IC50 | = | 2208.0 | nM | 5.66 |
| CHEMBL5423534 | — | IC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL5398223 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5417909 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5394490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5425458 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5413779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5403131 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5403709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5439019 | — | IC50 | > | 10000.0 | nM | - |