Assay Detail
Functional
CHEMBL5350195
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Hep3B cells incubated for 72 hrs by Cell counting kit 8 method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.70 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427478 | — | — | 1 | 7.88 |
| CHEMBL5436527 | — | — | 1 | 7.76 |
| CHEMBL5440092 | — | — | 1 | 7.52 |
| CHEMBL5431098 | — | — | 1 | 7.52 |
| CHEMBL5404060 | — | — | 1 | 7.52 |
| CHEMBL5413844 | — | — | 1 | 7.39 |
| CHEMBL5439595 | — | — | 1 | 7.28 |
| CHEMBL5409484 | — | — | 1 | 7.20 |
| CHEMBL5434390 | — | — | 1 | 7.18 |
| CHEMBL5411218 | — | — | 1 | 7.14 |
| CHEMBL5420584 | — | — | 1 | 7.14 |
| CHEMBL5410318 | — | — | 1 | 6.90 |
| CHEMBL5407229 | — | — | 1 | 6.50 |
| CHEMBL5425019 | — | — | 1 | 6.36 |
| CHEMBL5405058 | — | — | 1 | 6.35 |
| CHEMBL5432091 | — | — | 1 | 6.29 |
| CHEMBL5435060 | — | — | 1 | 6.18 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 6.16 |
| CHEMBL5403437 | — | — | 1 | 5.87 |
| CHEMBL5403709 | — | — | 1 | 5.78 |
| CHEMBL5425458 | — | — | 1 | 5.41 |
| CHEMBL5394490 | — | — | 1 | 5.39 |
| CHEMBL5439019 | — | — | 1 | 5.29 |
| CHEMBL5423534 | — | — | 1 | - |
| CHEMBL5413779 | — | — | 1 | - |
| CHEMBL5422680 | — | — | 1 | - |
| CHEMBL5403131 | — | — | 1 | - |
| CHEMBL5417909 | — | — | 1 | - |
| CHEMBL5419075 | — | — | 1 | - |
| CHEMBL5398223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427478 | — | IC50 | = | 13.27 | nM | 7.88 |
| CHEMBL5436527 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL5440092 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL5431098 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5404060 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL5413844 | — | IC50 | = | 41.05 | nM | 7.39 |
| CHEMBL5439595 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL5409484 | — | IC50 | = | 63.6 | nM | 7.20 |
| CHEMBL5434390 | — | IC50 | = | 66.17 | nM | 7.18 |
| CHEMBL5411218 | — | IC50 | = | 72.6 | nM | 7.14 |
| CHEMBL5420584 | — | IC50 | = | 72.6 | nM | 7.14 |
| CHEMBL5410318 | — | IC50 | = | 125.4 | nM | 6.90 |
| CHEMBL5407229 | — | IC50 | = | 312.7 | nM | 6.50 |
| CHEMBL5425019 | — | IC50 | = | 438.3 | nM | 6.36 |
| CHEMBL5405058 | — | IC50 | = | 450.4 | nM | 6.35 |
| CHEMBL5432091 | — | IC50 | = | 509.1 | nM | 6.29 |
| CHEMBL5435060 | — | IC50 | = | 664.1 | nM | 6.18 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 696.2 | nM | 6.16 |
| CHEMBL5403437 | — | IC50 | = | 1346.0 | nM | 5.87 |
| CHEMBL5403709 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5425458 | — | IC50 | = | 3929.0 | nM | 5.41 |
| CHEMBL5394490 | — | IC50 | = | 4025.0 | nM | 5.39 |
| CHEMBL5439019 | — | IC50 | = | 5078.0 | nM | 5.29 |
| CHEMBL5423534 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5413779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5403131 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5417909 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5419075 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5398223 | — | IC50 | > | 10000.0 | nM | - |