Assay Detail
Binding
CHEMBL5350396
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Binding affinity to human ERalpha D538G mutant ligand binding domain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.89 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623004 | AZD-9496 | 1.0 | 1 | 9.30 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623004 | AZD-9496 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 3.3 | nM | 8.48 |