Assay Detail
Binding
CHEMBL5350412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ERalpha degradation in human MCF7 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.37 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 9.70 |
| CHEMBL4475463 | AMCENESTRANT | 3.0 | 1 | 9.40 |
| CHEMBL5095210 | VEPDEGESTRANT | 3.0 | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4475463 | AMCENESTRANT | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5095210 | VEPDEGESTRANT | EC50 | = | 1.0 | nM | 9.00 |