Assay Detail
Binding
CHEMBL5350864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKR1C3 (unknown origin) dehydrogenase activity by measuring NADH formation by spectrophotometry
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.74 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5411357 | — | — | 1 | 7.40 |
| CHEMBL5417484 | — | — | 1 | 7.30 |
| CHEMBL5432550 | — | — | 1 | 7.30 |
| CHEMBL5436074 | — | — | 1 | 7.29 |
| CHEMBL5412889 | — | — | 1 | 7.22 |
| CHEMBL5437220 | — | — | 1 | 7.22 |
| CHEMBL5405662 | — | — | 1 | 7.16 |
| CHEMBL4467986 | — | — | 1 | 7.16 |
| CHEMBL5409918 | — | — | 1 | 7.10 |
| CHEMBL5409789 | — | — | 1 | 7.10 |
| CHEMBL5402185 | — | — | 1 | 7.05 |
| CHEMBL5427873 | — | — | 1 | 7.03 |
| CHEMBL5401206 | — | — | 1 | 7.03 |
| CHEMBL5440460 | — | — | 1 | 7.00 |
| CHEMBL5407493 | — | — | 1 | 7.00 |
| CHEMBL5408308 | — | — | 1 | 6.96 |
| CHEMBL5411768 | — | — | 1 | 6.96 |
| CHEMBL5408158 | — | — | 1 | 6.96 |
| CHEMBL5403375 | — | — | 1 | 6.96 |
| CHEMBL5401567 | — | — | 1 | 6.92 |
| CHEMBL5397612 | — | — | 1 | 6.89 |
| CHEMBL5422271 | — | — | 1 | 6.85 |
| CHEMBL5438117 | — | — | 1 | 6.77 |
| CHEMBL5421383 | — | — | 1 | 6.77 |
| CHEMBL5436263 | — | — | 1 | 6.77 |
| CHEMBL5412832 | — | — | 1 | 6.75 |
| CHEMBL5427049 | — | — | 1 | 6.72 |
| CHEMBL5411601 | — | — | 1 | 6.72 |
| CHEMBL5425839 | — | — | 1 | 6.70 |
| CHEMBL5403238 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5411357 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5417484 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5432550 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5436074 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5412889 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5437220 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5405662 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4467986 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5409918 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5409789 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5402185 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5427873 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5401206 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5440460 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5407493 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5408308 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5403375 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5408158 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5411768 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5401567 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5397612 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5422271 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5438117 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5421383 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5436263 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5412832 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5427049 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5411601 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5425839 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5403238 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5435345 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5406207 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5402839 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5397146 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5441078 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5424035 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5438808 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5411983 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5410143 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5417285 | — | IC50 | = | 28000.0 | nM | 4.55 |