Assay Detail
Functional
CHEMBL5350928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of colony formation in human HCT-116 cells preincubated for 1 hr followed by exposure to 2 Gy gamma irradiation and measured after 1 week by crystal violet staining based chemiluminescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.27 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3960662 | — | — | 1 | 9.34 |
| CHEMBL5411336 | — | — | 1 | 9.27 |
| CHEMBL5402194 | — | — | 1 | 8.81 |
| CHEMBL5419324 | — | — | 1 | 8.77 |
| CHEMBL5425392 | — | — | 1 | 8.75 |
| CHEMBL5434323 | — | — | 1 | 8.36 |
| CHEMBL5429982 | — | — | 1 | 8.27 |
| CHEMBL5423087 | — | — | 1 | 8.16 |
| CHEMBL5419474 | — | — | 1 | 8.15 |
| CHEMBL5438394 | — | — | 1 | 8.12 |
| CHEMBL5415162 | — | — | 1 | 8.05 |
| CHEMBL5407799 | — | — | 1 | 7.91 |
| CHEMBL5416391 | — | — | 1 | 7.81 |
| CHEMBL5438262 | — | — | 1 | 7.81 |
| CHEMBL4218734 | — | — | 1 | 7.70 |
| CHEMBL5398961 | — | — | 1 | 7.66 |
| CHEMBL5406188 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3960662 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL5411336 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL5402194 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL5419324 | — | IC50 | = | 1.69 | nM | 8.77 |
| CHEMBL5425392 | — | IC50 | = | 1.76 | nM | 8.75 |
| CHEMBL5434323 | — | IC50 | = | 4.35 | nM | 8.36 |
| CHEMBL5429982 | — | IC50 | = | 5.41 | nM | 8.27 |
| CHEMBL5423087 | — | IC50 | = | 6.97 | nM | 8.16 |
| CHEMBL5419474 | — | IC50 | = | 7.13 | nM | 8.15 |
| CHEMBL5438394 | — | IC50 | = | 7.65 | nM | 8.12 |
| CHEMBL5415162 | — | IC50 | = | 8.94 | nM | 8.05 |
| CHEMBL5407799 | — | IC50 | = | 12.22 | nM | 7.91 |
| CHEMBL5416391 | — | IC50 | = | 15.35 | nM | 7.81 |
| CHEMBL5438262 | — | IC50 | = | 15.42 | nM | 7.81 |
| CHEMBL4218734 | — | IC50 | = | 20.02 | nM | 7.70 |
| CHEMBL5398961 | — | IC50 | = | 21.91 | nM | 7.66 |
| CHEMBL5406188 | — | IC50 | = | 26.47 | nM | 7.58 |