Assay Detail
Toxicity
CHEMBL5352769
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Antiproliferative activity against human THLE-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | THLE-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.87 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399676 | — | — | 1 | 5.51 |
| CHEMBL5423110 | — | — | 1 | 5.24 |
| CHEMBL4863608 | — | — | 1 | 5.24 |
| CHEMBL5428936 | — | — | 1 | 5.14 |
| CHEMBL5428732 | — | — | 1 | 4.93 |
| CHEMBL5397056 | — | — | 1 | 4.88 |
| CHEMBL5437435 | — | — | 1 | 4.79 |
| CHEMBL5404090 | — | — | 1 | 4.76 |
| CHEMBL5437172 | — | — | 1 | 4.72 |
| CHEMBL5434343 | — | — | 1 | 4.68 |
| CHEMBL5435872 | — | — | 1 | 4.62 |
| CHEMBL5422540 | — | — | 1 | 4.56 |
| CHEMBL5410672 | — | — | 1 | 4.53 |
| CHEMBL5399692 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399676 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5423110 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4863608 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5428936 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5428732 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL5397056 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL5437435 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5404090 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5437172 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL5434343 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL5435872 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL5422540 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL5410672 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL5399692 | — | IC50 | = | 29900.0 | nM | 4.52 |