Assay Detail
Binding
CHEMBL5353382
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Inhibition of human GRK2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.04 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414047 | — | — | 1 | 7.75 |
| CHEMBL4090144 | — | — | 1 | 7.52 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414047 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4090144 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL490 | PAROXETINE | IC50 | = | 1380.0 | nM | 5.86 |