Assay Detail
Binding
CHEMBL5353387
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Inhibition of GRK2 (unknown origin) using CRRREEEEESAAA as substrate measured for 120 mins in presence of ATP by ADP-glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.52 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406336 | — | — | 1 | 6.63 |
| CHEMBL384073 | GSK-180736A | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406336 | — | IC50 | = | 236.4 | nM | 6.63 |
| CHEMBL384073 | GSK-180736A | IC50 | = | 390.0 | nM | 6.41 |