Assay Detail
Functional
CHEMBL5353552
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Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1,2-diphenylethene derivatives as human DNA topoisomerase II catalytic inhibitors and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399261 | — | — | 1 | 6.70 |
| CHEMBL5424300 | — | — | 1 | 6.22 |
| CHEMBL5418790 | — | — | 1 | 5.68 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399261 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5424300 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5418790 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2400.0 | nM | 5.62 |