Assay Detail
Binding
CHEMBL5353744
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Inhibition of human BChE using butyrylthiocholine iodide as substrate measured for 3 mins by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.54 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.52 |
| CHEMBL5416136 | — | — | 1 | 7.96 |
| CHEMBL5403451 | — | — | 1 | 7.80 |
| CHEMBL5405011 | — | — | 1 | 7.62 |
| CHEMBL5414031 | — | — | 1 | 7.57 |
| CHEMBL5435700 | — | — | 1 | 7.52 |
| CHEMBL5425810 | — | — | 1 | 6.75 |
| CHEMBL5436125 | — | — | 1 | 6.54 |
| CHEMBL5421870 | — | — | 1 | - |
| CHEMBL5414945 | — | — | 1 | - |
| CHEMBL5439234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5416136 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5403451 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5405011 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5414031 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5435700 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5425810 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5436125 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5421870 | — | IC50 | - | — | - | |
| CHEMBL5414945 | — | IC50 | - | — | - | |
| CHEMBL5439234 | — | IC50 | - | — | - |