Assay Detail
Binding
CHEMBL5354106
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Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addition and measured after 5 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.70 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 7.77 |
| CHEMBL5410682 | — | — | 1 | 5.57 |
| CHEMBL5436270 | — | — | 1 | 5.44 |
| CHEMBL5421285 | — | — | 1 | 5.43 |
| CHEMBL2018554 | — | — | 1 | 5.42 |
| CHEMBL5400279 | — | — | 1 | 5.40 |
| CHEMBL5418340 | — | — | 1 | 5.37 |
| CHEMBL5422642 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5410682 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL5436270 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5421285 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL2018554 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5400279 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5418340 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5422642 | — | IC50 | = | 6130.0 | nM | 5.21 |