Assay Detail
Functional
CHEMBL5354472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.15 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424343 | — | — | 1 | 6.37 |
| CHEMBL221890 | — | — | 1 | 6.28 |
| CHEMBL5428024 | — | — | 1 | 6.22 |
| CHEMBL5427668 | — | — | 1 | 6.17 |
| CHEMBL5398904 | — | — | 1 | 6.12 |
| CHEMBL5400431 | — | — | 1 | 6.06 |
| CHEMBL5430299 | — | — | 1 | 5.70 |
| CHEMBL5404022 | — | — | 1 | 5.64 |
| CHEMBL5430486 | — | — | 1 | 5.44 |
| CHEMBL5403142 | — | — | 1 | 5.35 |
| CHEMBL5440337 | — | — | 1 | 5.34 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | — | 1 | 5.20 |
| CHEMBL5424352 | — | — | 1 | 5.20 |
| CHEMBL5405364 | — | — | 1 | 5.19 |
| CHEMBL5405828 | — | — | 1 | 5.14 |
| CHEMBL5403576 | — | — | 1 | 5.10 |
| CHEMBL5395805 | — | — | 1 | 5.09 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 5.08 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 5.02 |
| CHEMBL5427078 | — | — | 1 | 5.00 |
| CHEMBL5436926 | — | — | 1 | 4.82 |
| CHEMBL487887 | URSONIC ACID | — | 1 | 4.80 |
| CHEMBL5408390 | — | — | 1 | 4.77 |
| CHEMBL472646 | MORONIC ACID | — | 1 | 4.77 |
| CHEMBL562059 | — | — | 1 | 4.75 |
| CHEMBL5393931 | — | — | 1 | 4.72 |
| CHEMBL5411079 | — | — | 1 | 4.66 |
| CHEMBL3134501 | — | — | 1 | 4.64 |
| CHEMBL2179603 | — | — | 1 | 4.62 |
| CHEMBL5439655 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424343 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL221890 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5428024 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5427668 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5398904 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5400431 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5430299 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5404022 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5430486 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5403142 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5440337 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5424352 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5405364 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5405828 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5403576 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5395805 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5427078 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5436926 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL487887 | URSONIC ACID | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5408390 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL472646 | MORONIC ACID | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL562059 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5393931 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5411079 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3134501 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2179603 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5439655 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5434622 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5429967 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5397295 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL5425414 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL5398712 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5411390 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5423517 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5422081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5428339 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3233721 | — | IC50 | > | 50000.0 | nM | - |