Assay Detail
Functional
CHEMBL5354473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-DNR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.05 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430486 | — | — | 1 | 6.31 |
| CHEMBL5427078 | — | — | 1 | 6.28 |
| CHEMBL221890 | — | — | 1 | 6.20 |
| CHEMBL5400431 | — | — | 1 | 5.85 |
| CHEMBL5398904 | — | — | 1 | 5.82 |
| CHEMBL5428024 | — | — | 1 | 5.80 |
| CHEMBL5424343 | — | — | 1 | 5.77 |
| CHEMBL5411079 | — | — | 1 | 5.70 |
| CHEMBL5427668 | — | — | 1 | 5.68 |
| CHEMBL3134501 | — | — | 1 | 5.62 |
| CHEMBL5404022 | — | — | 1 | 5.04 |
| CHEMBL5405828 | — | — | 1 | 5.00 |
| CHEMBL5405364 | — | — | 1 | 4.96 |
| CHEMBL5424352 | — | — | 1 | 4.96 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.96 |
| CHEMBL5403576 | — | — | 1 | 4.85 |
| CHEMBL5403142 | — | — | 1 | 4.85 |
| CHEMBL562059 | — | — | 1 | 4.85 |
| CHEMBL5393931 | — | — | 1 | 4.77 |
| CHEMBL472646 | MORONIC ACID | — | 1 | 4.77 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 4.77 |
| CHEMBL487887 | URSONIC ACID | — | 1 | 4.72 |
| CHEMBL5395805 | — | — | 1 | 4.72 |
| CHEMBL5436926 | — | — | 1 | 4.54 |
| CHEMBL5434622 | — | — | 1 | 4.40 |
| CHEMBL2179603 | — | — | 1 | 4.40 |
| CHEMBL5439655 | — | — | 1 | 4.32 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | — | 1 | 4.32 |
| CHEMBL5398712 | — | — | 1 | 4.31 |
| CHEMBL5408390 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430486 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5427078 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL221890 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5400431 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5398904 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5428024 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5424343 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5411079 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5427668 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3134501 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5404022 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5405828 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5405364 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5424352 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5403576 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL562059 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5403142 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5393931 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL472646 | MORONIC ACID | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL487887 | URSONIC ACID | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5395805 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5436926 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5434622 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2179603 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5439655 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5398712 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL5408390 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5397295 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5425414 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5440337 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5411390 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5430299 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5423517 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5422081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5428339 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3233721 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5429967 | — | IC50 | > | 50000.0 | nM | - |