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Assay Detail

CHEMBL5354885

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Binding
Inhibition of c-Myc to Max protein dimerization (unknown origin) by electrophoretic mobility shift assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

c-Myc/c-Max (CHEMBL4106127)
Type PROTEIN-PROTEIN INTERACTION
Organism Homo sapiens

Publication

Synthesis and biological evaluation of a novel c-Myc inhibitor against colorectal cancer via blocking c-Myc/Max heterodimerization and disturbing its DNA binding.
Huang Q, Pu C, Tan L, Wang S, Zhang H, Yu S, Deng R, Luo D, Ma X, Li R.
Eur J Med Chem (2022) 243 : 114779 -114779
PubMed 36209705 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.48 4.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1336889 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1336889 IC50 = 33000.0 nM 4.48