Assay Detail
Binding
CHEMBL5355298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tyrosinase in human MNT-1 cell lysates using L-DOPA as substrate assessed as reduction in melanin formation preincubated for 10 mins followed by substrate addition and measured by microplate reader analysis
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MNT-1 |
| Subcellular | Lysates |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.91 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399906 | — | — | 1 | 5.80 |
| CHEMBL5408197 | — | — | 1 | 5.80 |
| CHEMBL5416835 | — | — | 1 | 5.64 |
| CHEMBL5394983 | — | — | 1 | 5.47 |
| CHEMBL5274383 | — | — | 1 | 5.24 |
| CHEMBL5405017 | — | — | 1 | 5.24 |
| CHEMBL5428256 | — | — | 1 | 5.23 |
| CHEMBL1807311 | — | — | 1 | 5.19 |
| CHEMBL1807492 | — | — | 1 | 5.16 |
| CHEMBL1814444 | — | — | 1 | 5.11 |
| CHEMBL5404839 | — | — | 1 | 5.09 |
| CHEMBL450195 | RUCINOL | — | 1 | 5.08 |
| CHEMBL5412546 | — | — | 1 | 4.93 |
| CHEMBL5403418 | — | — | 1 | 4.90 |
| CHEMBL3978212 | — | — | 1 | 4.82 |
| CHEMBL5396899 | — | — | 1 | 4.82 |
| CHEMBL5396212 | — | — | 1 | 4.75 |
| CHEMBL5425960 | — | — | 1 | 4.74 |
| CHEMBL5418068 | — | — | 1 | 4.72 |
| CHEMBL1814434 | — | — | 1 | 4.60 |
| CHEMBL5394207 | — | — | 1 | 4.50 |
| CHEMBL5421537 | — | — | 1 | 4.32 |
| CHEMBL373249 | — | — | 1 | 4.22 |
| CHEMBL5418183 | — | — | 1 | 4.10 |
| CHEMBL5427200 | — | — | 1 | 4.10 |
| CHEMBL5405551 | — | — | 1 | 4.06 |
| CHEMBL5420730 | — | — | 1 | - |
| CHEMBL5400410 | — | — | 1 | - |
| CHEMBL5426749 | — | — | 1 | - |
| CHEMBL1374610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399906 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL5408197 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5416835 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5394983 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5274383 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5405017 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5428256 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1807311 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1807492 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1814444 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5404839 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL450195 | RUCINOL | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5412546 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL5403418 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL5396899 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3978212 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5396212 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5425960 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL5418068 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1814434 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5394207 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5421537 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL373249 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL5418183 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL5427200 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL5405551 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL5411705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5426205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5435799 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1172321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5432681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5399513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL287556 | KOJIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL5404928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5400587 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5397672 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5423130 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1374610 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5426749 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5400410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5420730 | — | IC50 | > | 100000.0 | nM | - |